👏 Thrilled to share a tremendous achievement with our contribution to an article accepted in Annals of Oncology
🔍 This publication emphasizes the prediction of response to immune checkpoint blockade in patients with metastatic #colorectal cancer with microsatellite instability. https://lnkd.in/dSGQcU4x
This work highlights :
1️⃣ Challenge TMB and MSISensor for predicting response to immunotherapy in MSI mCRC
2️⃣ Demonstration that MSI misdiagnoses lead to a false ability of TMB and MSISensor to predict ICI resistance in MSI mCRC.
3️⃣ Identification and validation of DNA and RNA signatures predictive of response to ICI in these patients with mCRC MSI
4️⃣ Evidence for a fibrosis signature associated with functional ICI resistance in MSI mCRC

Huge thanks to everyone involved CRSA PARIS Inserm Sorbonne Université SiRIC CURAMUS Ligue contre le cancer AP-HP, Assistance Publique – Hôpitaux de Paris Institut du Cerveau – Paris Brain Institute CRI – Centre de Recherche sur l’Inflammation Centre Léon Bérard MSInsight